Blood Cells - Tissue Functioning and Remodeling in the Circulatory and Ventilatory Systems - page 102

Table 3.15. Molecules of mastocytes (Source: [ 194 ]). ( Part 2 ) Growth factors (HBEGF:

heparin-binding EGF-like growth factor).

Stem cell factor Melanocyte growth

Nerve growth factor Modulation of mastocyte activity,

hair growth,
neuron growth and differentiation

Fibroblast growth factor-2/5/7/10 Tissue remodeling

Transforming growth factor- β Wound healing

Vascular endothelium growth factor Blood vessel permeability, angiogenesis

Platelet-derived growth factor Fibroblast growth, angiogenesis

Epidermal growth factor Keratinocyte growth and differentiation

HBEGF Keratinocyte growth and differentiation

Granulocyte-macrophage Langerhans cell migration and maturation,

colony-stimulating factor (CSF2) angiogenesis

Table 3.16. Molecules of mastocytes (Source: [ 194 ]). ( Part 3 ) Cytokines and chemokines (MCP:
monocyte chemoattractant protein, MCP1 to MCP3 being CCL2, CCL8, and CCL7 chemokines,
respectively; MIP: macrophage inflammatory protein, MIP1 α to MIP1 δ being CCL3, CCL4,

CCL9, and CCL15, respectively).

TNF α Expression of endothelial leukocyte adhesion molecule-1

Promotion of IL8 synthesis
Neutrophil recruitment
T-cell recruitment
Lymph node hypertrophy (adaptive immune response)
Langerhans cell migration
Interleukin-1, IL3-IL6, IL8, IL10, IL11, IL13, and IL16

IL3 Keratinocyte growth and differentiation

IL4 Langerhans cell migration and maturation

IL8 Granulocyte recruitment and activation

Melanocyte growth

IL10 Tolerance induction

Chemokines

CCL2 (MCP1) Chemotaxis

CCL3 (MIP α ) Chemotaxis

Miscellaneous

Neuropeptides Communication with the nervous system

Endothelin-1 Vasoconstriction

Under normal conditions, skin mastocytes are preferentially located close to
nerves, especially sensory nerve endings, 91 blood vessels, and hair follicles. Hair
follicle cycling during periods of rest and growth, which is associated with

91 Axon plexi can surround superficial dermal mastocytes.