Biology Reference
In-Depth Information
Figure 2.11.
Schemeoftheaptasensorbasedontheformationofahybrid
containing the thrombin aptamer, strand displacement, and signal amplifi-
cation via QD.
2.10 Conclusions
In this chapter several applications of aptamers in the development
ofelectrochemicalbiosensorshavebeenreported.Differentelectro-
chemical methods based on aptamers have been considered both
for the detection of proteins (PDGF, VEGF, lysozyme, or thrombin)
or smallmolecules.
Aptamer-based assays opened new scenarios in the field of ana-
lytical chemistry. New combinations of aptamer-based biosensors
with innovative ideas in molecular biology, electrochemistry, and
nanotechnologies are encouraged and expected with aim of devel-
oping easy, sensitive, selective, andfast analytical methods.
References
1. G. Mayer, The chemical biology of aptameters,
Angew. Chem. Int
.
Ed.
,
48
,
2672 (2009).
2. I. Willner and M. Zayats, Electronic aptamer-based sensors,
Angew.
Chem. Int. Ed.
,
46
(34),6408-6418 (2007).
