Biology Reference
In-Depth Information
of LNA are increased. It was shown that the melting temperatures
of LNA-RNA and LNA-DNA double strands are higher than those
of DNA-RNA and DNA-DNA. Therefore, it is expected that LNA
single strand may accomplish stronger hybridization with DNA as
well as RNA. It is used to increase the specificity and sensitivity of
oligonucleotide-basedDNA-biosensors(Mukhopadhyay
et al
.,2005;
Natsume
et al
., 2007).
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