Biology Reference
In-Depth Information
Figure 14.9.
Scanning electron micrographs and schematic illustrations
of 2D (A) and 3D (B) gold nanowire electrodes. (C) Modification of the gold
nanowireelectrodeswiththiolatedprobeDNA,subsequenthybridizationof
target DNA, and detection via electrocatalysis of Ru(III)/Fe(III).
this work femtomolar levels of DNA, as well as an RNA sequence
relevant to prostate cancer, were detected in unamplified patient
samples.
Gold nanowire arrays were also used by Andreu and coworkers
for DNA detection [45]. Anodic aluminum oxide membranes were
used as templates for galvanostatic Au electrodeposition followed
by treatment in base to dissolve away the template leaving free-
standing gold nanowires 330 nm in diameter and
min
length. [Ru(NH
3
)
6
]
3
+
was used to measure charge before and after
∼
2
μ
