Biology Reference
In-Depth Information
Chapter 14
DNA Detection
Ronen Polsky, Jason C. Harper, and Susan M. Brozik
Biosensors & Nanomaterials, Sandia National Laboratories,
PO Box 5800, MS-0892, Albuquerque, NM 87185, USA
rpolsky@sandia.gov
The combination of nanomaterials and biomolecules has led to a
new generation of DNA sensing devices. Taking advantage of the
size-dependent properties of nanomaterials and the unique inter-
facial phenomenon that result in their coupling with electrochem-
ical transducers, many different biosensing strategies have been
realized. The use of nanoparticles, various nanowires, nanotubes,
nanorods, etc. have all been incorporated into novel DNA sensing
schemes. Thus, the field of biotechnology has recently witnessed
extensiveprogressintheuseofnanomaterial-basedelectrochemical
DNA sensors.
14.1 Introduction
The field of biotechnology has witnessed extensive progress over
the past decade in the use of nanomaterials to develop novel
biosensors and electrochemical bioassays [1]. Perhaps the most
