Biology Reference
In-Depth Information
Figure 13.5.
Schematic illustration of electrochemical label-free allele-
specific genosensing method.
endpartoftheamplicon(closetoprimers)causedduplexformation
at the posterior of the long sequence, however, the probe chosen in
the middle section of the amplicon prevent the duplex formation
and stabilize the amplicon sequence for hybridization and provide
an optimum diagnosis.
Direct bioelectronic detection of multiple point mutations in
Mycobacterium tuberculosis amplicons related to rifampin drug
resistance was perfomed [98]. In recent studies, it was found that
95% of RIF-resistant bacteria strains possess mutations within
