Biology Reference
In-Depth Information
Chapter 12
Electrochemical DNA Biosensors for
Detection of Compound-DNA
Interactions
D. Ozkan-Ariksoysal, P. Kara, and M. Ozsoz
Department of Analytical Chemistry, Faculty of Pharmacy, Ege University,
35100, Bornova, Izmir, Turkey
dilsat.ariksoysal@ege.edu.tr
The interactions of some compounds such as anticancer drugs with
DNA have been performed by a variety of techniques. In recent
times electrochemical DNA biosensor systems have been taking an
increasinginterestintheanalysisofcompound-DNAinteractionsfor
understanding the action mechanism of many chemical molecules
due to their high sensitivity, portability, low-cost structure, single-
use property, and compatibility with microfabrication technology.
Based on these electrochemical methods, binding of compounds
onto DNA and/or general DNA damage occurred by these com-
pounds, have been identified by using the voltammetric signals
of guanine, adenine, or related compound molecules. In most of
these applications for the detection of compound-DNA interactions,
anticancer drugs have been studied because of their known effects
on DNA molecule.
 
 
 
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