Biology Reference
In-Depth Information
elimination, Table 11.1), the electrochemical process can be eval-
uated in detail. Using kinetic current component elimination, the
extendingpotentialwindowcanbeachieved.Generally,AdSEVLSor
AdTSEVLSE4peak-counterpeaksareanorderofmagnitudehigher
than their corresponding LSV signals and, moreover, do not require
baselinecorrection.
It was found that EVLS is capable to detect (i) minor signals
hidden in major ones, (ii) small changes in ODN structure and the
interactionbetweenODNandelectrode surface, and(iii)potentially
closed signals (resolution of overlapped peaks). On the basis of
the above-mentioned advantages, EVLS in connection with the
adsorptionprocedurefulfillstherequirementsforaperspectiveand
promisingtoolforqualitativeandquantitativestudiesinbioanalysis
in bio- and nanotechnologies. Therefore, the implementation of
EVLSin electrochemical analyzersshould beof great interest.
Acknowledgement
This work was supported by the Ministry of Education, Youth and
Sports of the Czech Republic (INCHEMBIOL MSM0021622412 and
BIO-ANAL-MED LC06035), the Academy of Sciences of the Czech
Republic (grant A400040804), the Czech Grant Foundation GACR
(P205/10/2378), and institutional research plans of the Institute of
Biophysics (AV0Z50040507, AV0Z50040702).
References
1. R. N. Adams,
Electrochemistry at solid electrodes
Marcel Dekker, New
York (1969).
2. C. M. A. Brett and A. M. O. Brett,
Electrochemistry. Principles, Methods,
and Applications
Oxford University Press, Oxford (1993).
3. Z. Galus,
Fundamentals of Electrochemical Analysis
Ellis Horwood and
Polish Scientific Publishers, New York and Warsaw (1994).
4. A.J.BardandL.R.Faulkner,
Electrochemical methods: Fundamentals and
applications
, John Wiley and Sons, New York (2000).
5. O.Dracka,
J. Electroanal. Chem.
402
,18 (1996).
