Biology Reference
In-Depth Information
Chapter 6
Peng Li,
a
Piero Migliorato,
a
and Pedro Estrela
b
a
Department of Engineering, University of Cambridge,
Electrical Engineering Division, Cambridge CB3 0FA, United Kingdom
b
Department of Electronic & Electrical Engineering, University of Bath,
Bath BA2 7AY, United Kingdom
pl281@cam.ac.uk; pm@eng.cam.ac.uk; p.estrela@bath.ac.uk
Biotechnology is in great need of low-cost intelligent biochips
capable of massive parallel detection to be used in portable
instrumentation. One way this may be achieved is by exploiting
mature semiconductor technologies for the development of biosen-
sor arrays. We review here two highly promising techniques for
label-free electrical detection of DNA hybridization: potentiometric
detection and electrochemical impedance spectroscopy. Field-effect
transistor technologies can play an important role in the develop-
ment ofthese techniques in biosensormicroarrays.
6.1 Introduction
The ability to detect biomolecular interactions is crucial in med-
ical, pharmaceutical, and biotechnological applications. The most
