Biology Reference
In-Depth Information
Table 4.3. Electrochemical genosensors based on dsDNA-intercalated
electrochemical labels
Modified Electrode
Detection
Analyte
Substrate
Technique
Detection Limit Reference
DNA synthetic strands
AuE
DPV(MB)
0.1 pM
47
Adenosine
AuE
DPV (MB)
1 nM
48
Helicobacter pyroli
AuE
DPV[Ru(NH
3
)
5
L
]
25 p ol
13
DNA sequence
Thrombin
GCE
DPV (MB)
0.5 nM
49
DNA synthetic strands
AuE
DPV (doxorubicin)
7.5 pM
20
DPV [Co(phen)
2
]
2
+
2.0
×
10
−
11
M44
DNA synthetic strands
AuE
ATP
AuE
DPV (MB)
0.1 nM
45
DNA synthetic strands
AuE
DPV (doxorubicin)
6.2 pM
46
10
−
13
M23
×
DNA synthetic strands
GCE
DPV(adryamicin) 3.5
AuE: gold electrode; DPV: differential pulse voltammetry; EIS: electrochemical impedance spec-
troscopy; GCE: glassy carbon electrode; (Ru(NH
3
)
5
L
: pentaamin ruthenium [3-(2-phenanthren-
9-yl-vinyl)-pyridine] complex.
Figure 4.8.
Scheme displaying the fundamentals and electrochemical
detection of DNA hybridization through bio-bar code DNA probes of
amplification [50] (reprinted with permission of Elsevier).
