SaaS Clouds Supporting Biology and Medicine - Cloud Computing with e-Science Applications - page 262

FIGURE 11.11
EXP-PAC query interface.

TABLE 11.4
Mutated Genes Present in the
GSM721140 Data Set

Gene Symbol Counts Mutation Score

TP53 4 3

PIK3CA 0 0

MAP3K1 0 0

GATA3 0 0

FOXA1 0 0

PTEN 0 0

TABLE 11.5
Basal-like Indicative Genes Present
in the GSM721140 Data Set

Gene Symbol Counts Mutation Score

KRAS 7 2

EGRF 2 0

FGFR2 1 0

MET 1 1

nonmutated genes known to be present in basal-like breast cancer tumors
(see Table 11.5) further validated this finding. Four of eight known basal-
like indicative genes were shown to be present in the GSM721140 data
set. Two genes, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
(KRAS) and epidermal growth factor receptor (EGRF), were shown to be
highly regulated, while fibroblast growth factor receptor 2 (FGFR2) and
mesenchymal-epithelial transition factor (MET) were present.