Gene Therapy for Epilepsies - Gene Delivery and Therapy for Neurological Disorders - page 236

Table 1
(countined)

Target gene Injection region Vector Experimental model Functional outcome References

NpHR 2.0 Motor cortex Lentivirus-Camk2a-

NpHR 2.0

Tetanus toxin injection
into the motor cortex

Reduced EEG seizures Wykes et al. [ 61 ]

Kv1.1 Motor cortex Lentivirus-CMV-Kv1.1 Tetanus toxin injection

into the motor cortex

Prevented toxin-induced EEG seizures
and spontaneous recurrent seizures;
progressively suppressed epileptic
activity in an established epileptic focus

Wykes et al. [ 61 ]

Abbreviations : A AV adeno-associated virus, Ad adenoviral, ADA adenosine deaminase, ADK adenosine kinase, ASPA aspartoacylase, Bcl-2 B-cell lymphoma 2, BDNF brain-
derived neurotrophic factor, β-gal ʲ-galactosidase, BHK baby hamster kidney, Camk2a calcium/calmodulin-dependent protein kinase II alpha, CBA cytomegalovirus enhancer
with a chicken beta-actin promoter, CCK cholecystokinin, CMV cytomegalovirus, CT1 cardiotrophin 1, EEG electroencephalographic, EPM elevated plus maze, FIB ibronectin
secretory signal peptide, FGF-2 basic ibroblast growth factor-2, FST forced swim test, GABAR gamma-aminobutyric acid A receptor, GAD glutamic acid decarboxylase, GAL
galanin, GDNF glial-derived neurotrophic factor, GfaABC1D glial ibrillary acidic protein (GfaABC1D) promoter, GT GlutI glucose transporter, HCMV human cytomegalovi-
rus, HSP72 heat shock protein 72, HSV herpes simplex virus, ICP0 infected cell polypeptide 0, ICP10PK ICP 10 protein kinase, i.c.v. intracerebroventricular, KA kainic acid,
Kv1.1 Kv1 potassium channel, NpHR2.0 Natronomonas pharaonis halorhodopsin, NPY neuropeptide Y, NR1 N -methyl-d-aspartate receptor 1, NSE neuron-speciic enolase,
NT-3 neurotrophin 3, OF open ield test, SST somatostatin, pSV plasmid vector with Simian virus 40 promoter, TET off tetracycline-off regulatable promoter, tg transgene, TLE
temporal lobe epilepsy, TST tail suspension test