Gene Therapy for Epilepsies - Gene Delivery and Therapy for Neurological Disorders - page 233

Hippocampus AAV-NSE-NPY Electrophysiological

analysis

Attenuated long-term potentiation
in CA1-subicular synapses

Sorensen et al. [ 70 ]

Hippocampus AAV-NSE-NPY Rapid kindling Reduced seizures Sorensen et al. [ 30 ]

Hippocampus AAV-NSE-Y1 Behavioral analysis Modest anxiolytic-like effect in OF,

EPM; no effect in TST and FST

Olesen et al. [ 28 ]

Hippocampus AAV-NSE-Y1 Systemic KA Modestly aggravated KA-induced

seizures

Olesen et al. [ 28 ]

Hippocampus,
Amygdala

AAV-NSE-Y5 Behavioral analysis No effect on anxiety- and depressive-

like behaviors, moderate
hyperactivity in OF

Olesen et al. [ 32 ]

Hippocampus,
Amygdala

AAV-NSE-Y5 Systemic KA No effect Olesen et al. [ 32 ]

Somatostatin Hippocampus AAV-SST Amygdala kindling Reduced severe seizures Zafar et al. [ 38 ]

Adenosine Lateral ventricles Adenosine releasing

ADK deicient baby
hamster kidney cells
(BHK)

Kindling Reduced EEG and behavioral

seizures

Huber et al. [ 43 ]

Lateral ventricle Adenosine releasing

ADA deicient
ibroblast

Kindling Reduced EEG and behavioral

seizures

Huber et al. [ 43 ]

Lateral ventricles Adenosine releasing

ADK−/− mouse
embryonic stem cells

Kindling Reduced EEG and behavioral

seizures

Guttinger et al. [ 44 ]

Lateral ventricles Adenosine releasing

ADK−/− mouse
C2C12 myoblasts

Kindling Reduced EEG and behavioral

seizures

Guttinger et al. [ 44 ]

(continued)