Biomedical Engineering Reference
In-Depth Information
Fig. 4
Surgical procedure for access to the dorsal intrathecal space. (
a
) Incision of the skin at the base of the
skull exposes the superfi cial muscles (m. levator auris and m. platysma). (
b
) Both muscles are split over the
midline and retracted laterally, which exposes the underlying deeper muscle (m. rectus capitis) attached to the
occipital bone. (
c
) After retraction of the m. rectus capitis the
yellow
-colored atlanto-occipital membrane
becomes visible, which is then removed using forceps. (
d
) Removal of the atlanto-occipital membrane exposes
the foramen magnum, which grants access to the spinal cord and cisterna magna. The dura mater is opened
to access the arachnoid space. (
e
) The catheter is slowly inserted 8.5 cm into the dorsal intrathecal space
using two forceps after which injection of the viral vector is performed
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