Biomedical Engineering Reference
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128 mouse model of Huntington's disease.
Behav Brain Res 214(2):193-200
16. Kordower JH, Charles V, Bayer R et al (1994)
Intravenous administration of a transferrin
receptor antibody-nerve growth factor conju-
gate prevents the degeneration of cholinergic
striatal neurons in a model of Huntington
disease. Proc Natl Acad Sci U S A 91(19):
9077-9080
17. Baquet ZC, Gorski JA, Jones KR (2004) Early
striatal dendrite deficits followed by neuron
loss with advanced age in the absence of antero-
grade cortical brain-derived neurotrophic fac-
tor. J Neurosci 24(17):4250-4258
18. Strand A, Baquet Z, Aragaki A et al (2007)
Expression profiling of Huntington's disease
models suggests that brain-derived neuro-
trophic factor depletion plays a major role in
striatal degeneration. J Neurosci 27(43):
11758-11768
19. Altar C, Cai N, Bliven T et al (1997)
Anterograde transport of brain-derived neuro-
trophic factor and its role in the brain. Nature
389(6653):856-860
20. Zuccato C, Cattaneo E (2007) Role of brain-
derived neurotrophic factor in Huntington's
disease. Prog Neurobiol 81(5):294-330
21. Gauthier LR, Charrin BC, Borrell-Pag￨s M
et al (2004) Huntingtin controls neurotrophic
support and survival of neurons by enhancing
BDNF vesicular transport along microtubules.
Cell 118(1):127-138
22. Ferrer I, Goutan E, Marin C et al (2000) Brain-
derived neurotrophic factor in Huntington dis-
ease. Brain Res 866(1-2):257-261
23. Cattaneo E, Zuccato C, Tartari M (2005)
Normal huntingtin function: an alternative
approach to Huntington's disease. Nat Rev
Neurosci 6(12):919-930
24. Giralt A, Rodrigo T, Martin E et al (2009)
Brain-derived neurotrophic factor modulates
the severity of cognitive alterations induced
by mutant huntingtin: involvement of phos-
pholipaseC [gamma] activity and glutamate
receptor expression. Neuroscience 158(4):
1234-1250
25. Canals JM, Pineda JR, Torres-Peraza JF et al
(2004) Brain-derived neurotrophic factor reg-
ulates the onset and severity of motor dys-
function associated with enkephalinergic
neuronal degeneration in Huntington's disease.
J Neurosci 24(35):7727-7739
26. Ciammola A, Sassone J, Cannella M et al
(2007) Low brain-derived neurotrophic factor
(BDNF) levels in serum of Huntington's dis-
ease patients. Am J Med Genet B Neuropsychiatr
Genet 144(4):574-577
27. Kells AP, Fong DM, Dragunow M et al (2004)
AAV-mediated gene delivery of BDNF or
GDNF is neuroprotective in a model of
Huntington disease. Mol Ther 9(5):682-688
28. Kells A, Henry R, Connor B (2008) AAV-
BDNF mediated attenuation of quinolinic
acid-induced neuropathology and motor func-
tion impairment. Gene Ther 15(13):966-977
29. Frim DM, Uhler TA, Short MP et al (1993)
Effects of biologically delivered NGF, BDNF
and bFGF on striatal excitotoxic lesions.
Neuroreport 4(4):367-370
30. Ip N, Yancopoulos G (1996) The neurotroph-
ins and CNTF: two families of collaborative
neurotrophic factors. Annu Rev Neurosci
19:491-515
31. Emerich DF, Lindner MD, Winn SR et al
(1996) Implants of encapsulated human
CNTF-producing fibroblasts prevent behav-
ioral deficits and striatal degeneration in a
rodent model of Huntington's disease. J
Neurosci 16(16):5168-5181
32. de Almeida LP, Zala D, Aebischer P et al
(2001) Neuroprotective effect of a CNTF-
expressing lentiviral vector in the quinolinic
acid rat model of Huntington's disease.
Neurobiol Dis 8(3):433-446
33. Regulier E, Pereira de Almeida L, Sommer B
et al (2002) Dose-dependent neuroprotective
effect of ciliary neurotrophic factor delivered
via tetracycline-regulated lentiviral vectors in
the quinolinic acid rat model of Huntington's
disease. Hum Gene Ther 13(16):1981-1990
34. Mittoux V, Joseph JM, Conde F et al (2000)
Restoration of cognitive and motor functions
by ciliary neurotrophic factor in a primate
model of Huntington's disease. Hum Gene
Ther 11(8):1177-1188
35. Bachoud-L￩vi AC, Deglon N, Nguyen JP et al
(2000) Neuroprotective gene therapy for
Huntington's disease using a polymer encapsu-
lated BHK cell line engineered to secrete
human
CNTF.
Hum
Gene
Ther
11(12):1723-1729
36. Bloch J, Bachoud-L￩vi A, D￩glon N et al
(2004) Neuroprotective gene therapy for
Huntington's disease, using polymer-
encapsulated cells engineered to secrete human
ciliary neurotrophic factor: results of a phase I
study. Hum Gene Ther 15(10):968-975
37. Mittoux V, Ouary S, Monville C et al (2002)
Corticostriatopallidal neuroprotection by
adenovirus-mediated ciliary neurotrophic factor
gene transfer in a rat model of progressive striatal
degeneration. J Neurosci 22(11):4478-4486
38. Zala D, Bensadoun J, Pereira AL et al (2004)
Long-term lentiviral-mediated expression of
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