Biomedical Engineering Reference
In-Depth Information
AAV6
Human
Muscle, liver, spinal
cord [
110
]
Spinal cord [
110
]
2,3 N/2,6
N
-sialic
acid [
111
]
EGFR [
131
]
AAV7
Rhesus
monkey
Muscle [
39
] [
110
],
liver [
110
]
N
-sialic acid
[
110
]
PDGFR [
110
]
AAV8
Rhesus
monkey
Liver [
132
], heart, pancreas,
muscle, CNS [
33
,
40
,
42
],
eye [
110
]
Hippocampus [
40
],
retina [
40
]
Unknown
LamR [
116
]
Hemophilia B [
46
]
AAV9
Cynomolgus
monkey
Heart [
133
], lung, muscle,
liver [
37
,
39
,
134
], CNS
[
33
,
43
] [
41
]
Hippocampus,
striatum, cortex
[
34
,
41
], dorsal
root ganglia, spinal
cord [
43
]
N
-galactose [
135
] LamR [
116
]
Yes [
41
,
43
,
44
]
AAV10
Cynomolgus
monkey
CNS, muscle, liver [
110
,
136
,
137
], spleen, lymph
node [
136
]
Striatum [
34
], nucleus
accumbens [
137
]
Unknown
Unknown
AAV11
Cynomolgus
monkey
Spleen, lymph node [
136
]
Unknown
Unknown
AAV12
African green
monkey
Nasal epithelia [
138
]
Unknown
Unknown
AAV2.5
AAV2 with 5
amino acid
mutations
from AAV1
Muscle [
49
]
Duchenne muscular
dystrophy [
49
]
SNpc
substantia nigra pars compacta,
SNpr
substantia nigra pars reticulata,
HSPG
heparan sulfate proteoglycan,
HGFR
hepatic growth factor receptor,
EGFR
epidermal growth factor receptor,
FGFR1
fi broblast growth factor receptor 1,
PDGFR
platelet-derived growth factor receptor,
LamR
37/67-kDa Laminin receptor
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