Biology Reference
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inhibitory effects of this pathway focused on the inactivation of RhoA by
C3 transferase and the inhibition of ROCK by Fasudil, Y-27632, and
p21
Cip1/WAF1
(
Tonges, Koch, Bahr, et al., 2011
). Numerous studies investi-
gated these compounds in a variety of rat/mouse SCI models (
Chan et al.,
2005; Dergham et al., 2002; Fournier et al., 2001; Nishio et al., 2006;
Sung et al., 2003; Tanaka et al., 2004
;
Table 7.2
). After immediate or
delayed, local or systemic application, these compounds yielded different
Table 7.2 Analysis of preclinical studies focusing on rhoA inactivation/rho kinase
inhibition in terms of structural and functional repair
Tissue
sparing
Scar
reduction
Axon
sprouting
Axon
regeneration Behavior
C3 transferase
Dergham et al.
(2002)
?
?
þ
þ
Sung et al. (2003)
?
?
?
?
Fournier et al. (2001)
þ
Y27632
Dergham et al.
(2002)
?
?
þ
þ
Sung et al. (2003)
?
?
?
?
Fournier et al. (2001)
þ
Tanaka et al. (2004)
?
þ
þ
þ
Chan et al. (2005)
?
?
þ
þ
Fasudil
Sung et al. (2003)
?
?
?
þ
þ
Tanaka et al. (2004)
þ
?
þ
þ
Nishio et al. (2006)
?
?
?
þ
þ
p21
Cip1/WAF1
Tanaka et al. (2004)
?
þ
þ
þ
BA-210
Lord-Fontaine et al.
(2008)
þ
?
?
?
þ
þ
, positive effect;
, negative effect; ?, respective analysis not performed/reported.
