Biology Reference
In-Depth Information
Table 4.1 Summary of the effects of 5HT and its receptor subtypes manipulations on neurite, dendrite, and axon growth or guidance
—
cont'd
Effected
target
Manipulation Species
Neuron type
Model system
Effect
References
Thalamic neurons Neurite
In vitro
Htr3
Embryonic
mouse
Increase
Persico et al. (2006)
Htr3
Embryonic
rat
Cortical non-
GABAergic neurons
Axon
and
dendrite
In vitro
Decrease
Hayashi et al. (2010)
Htr3
Embryonic
rat
Cortical GABAergic
neurons
Axon
and
dendrite
In vitro
No effect
Hayashi et al. (2010)
Htr3A
Postnatal
mouse
Cortical neurons
Dendrite
In vivo
KO
Increase
Chameau et al. (2009)
,
Smit-Rigter et al. (2011)
, and
van der Velden et al. (2012)
Htr4
Postnatal
mouse
Hippocampal
neurons
Neurite
In vitro
Decrease
Kvachnina et al. (2005)
Htr7
Postnatal
mouse
Hippocampal
neurons
Neurite
In vitro
Increase
Kvachnina et al. (2005)
Htr7
Adult mouse Hippocampal
neurons
Neurite
In vitro
No effect
Kobe et al. (2012)
Htr7
Postnatal
mouse
Hippocampal
neurons
Dendrite
Ex vivo
Increase
Kobe et al. (2012)
Htr7
Postnatal rat Retinal ganglion cells Neurite
In vitro
Decrease
Authors' unpublished data
