The Role of Serotonin in Axon and Dendrite Growth - International Review of Neurobiology - page 115

Table 4.1 Summary of the effects of 5HT and its receptor subtypes manipulations on neurite, dendrite, and axon growth or guidance cont'd

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Effected
target Manipulation Species Neuron type Model system Effect References

Htr1B/D Mouse Thalamic neurons Axon Ex vivo Converted

attraction exerted by
netrin-1 to repulsion

Bonnin et al. (2007)

Htr1B/D Mouse Thalamic neurons Axon In vivo knockdown

or overexpression

Altered guidance Bonnin et al. (2007)

Htr2A Postnatal rat Purkinje cells Dendrite Ex vivo Decrease Kondoh et al. (2004)

Htr2A Embryonic

mouse

Serotonergic neurons Neurite Ex vivo Decrease Dudok et al. (2009)

Thalamic neurons Neurite In vitro Htr2A Embryonic

mouse

Increase Persico et al. (2006)

Htr2A Embryonic

rat

Cortical
glutamatergic
neurons

Neurite In vitro No effect (survival

increased)

Dooley et al. (1997)

Htr3A Mammalian

cell line

PC12 cells Neurite In vitro Increase Homma et al. (2006) , Severin

and Kondratyev (1988) , and
Solem et al. (1995)

Htr3 Embryonic

mouse

Thalamic neurons Neurite In vitro No effect Lotto et al. (1999)

Htr3 Embryonic

rat

Cortical GABAergic
neurons

Neurite In vitro Increase Vitalis and Parnavelas (2003)

Continued