Biology Reference
In-Depth Information
cells, which rapidly recycles adhesion components including
b
1 integrins
and is marked by trafficking molecules including Rab11 (
Howes et al.,
2010
). This pathway has not been investigated in neurons, but is remarkably
similar to a high capacity plasma membrane recycling phenomenon de-
scribed at the growth cone, where bulk endocytosis is used for rapid retrieval
of the growth cone membrane (
Bonanomi et al., 2008; Hines, Henle,
Carlstrom, Abu-Rub, & Henley, 2012
).
It is clear then that we are just beginning to understand integrin traffick-
ing process at the growth cone, and it will be important to continue these
studies to determine which processes are essential, and which process may be
lacking in axons with poor intrinsic growth abilities.
REFERENCES
Andrews, M. R., Czvitkovich, S., Dassie, E., Vogelaar, C. F., Faissner, A., & Blits, B. (2009).
Alpha9 integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon
regeneration.
The Journal of Neuroscience
,
29
, 5546-5557.
Anitei, M., & Hoflack, B. (2012). Bridging membrane and cytoskeleton dynamics in the se-
cretory and endocytic pathways.
Nature Cell Biology
,
14
, 11-19.
Anthis, N. J., & Campbell, I. D. (2011). The tail of integrin activation.
Trends in Biochemical
Sciences
,
36
, 191-198.
Arimura, N., Kimura, T., Nakamuta, S., Taya, S., Funahashi, Y., Hattori, A., et al. (2009).
Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and
Rab27.
Developmental Cell
,
16
, 675-686.
Arjonen, A., Alanko, J., Veltel, S., & Ivaska, J. (2012). Distinct recycling of active and inac-
tive beta1 integrins.
Traffic
.
Arnold, D. B. (2009). Actin and microtubule-based cytoskeletal cues direct polarized
targeting of proteins in neurons.
Science Signaling
,
2
, 49.
Ascano, M., Richmond, A., Borden, P., & Kuruvilla, R. (2009). Axonal targeting of Trk
receptors via transcytosis regulates sensitivity to neurotrophin responses.
The Journal of
Neuroscience
,
29
, 11674-11685.
Askari, J. A., Buckley, P. A., Mould, A. P., & Humphries, M. J. (2009). Linking integrin
conformation to function.
Journal of Cell Science
,
122
, 165-170.
Bareyre, F. M., Garzorz, N., Lang, C., Misgeld, T., Buning, H., & Kerschensteiner, M.
(2011). In vivo imaging reveals a phase-specific role of STAT3 during central and pe-
ripheral nervous system axon regeneration.
Proceedings of the National Academy of Sciences
of the United States of America
,
108
, 6282-6287.
Bass, M. D., Williamson, R. C., Nunan, R. D., Humphries, J. D., Byron, A.,
Morgan, M. R., et al. (2011). A syndecan-4 hair trigger initiates wound healing through
caveolin- and RhoG-regulated integrin endocytosis.
Developmental Cell
,
21
, 681-693.
Bel, C., Oguievetskaia, K., Pitaval, C., Goutebroze, L., & Faivre-Sarrailh, C. (2009). Axonal
targeting of Caspr2 in hippocampal neurons via selective somatodendritic endocytosis.
Journal of Cell Science
,
122
, 3403-3413.
Blackmore, M., & Letourneau, P. C. (2006). L1, beta1 integrin, and cadherins mediate ax-
onal regeneration in the embryonic spinal cord.
Journal of Neurobiology
,
66
, 1564-1583.
Bodrikov, V., Solis, G. P., & Stuermer, C. A. (2011). Prion protein promotes growth cone
development through reggie/flotillin-dependent N-cadherin trafficking.
The Journal of
Neuroscience
,
31
, 18013-18025.
