Information Technology Reference
In-Depth Information
We re-iterated the same procedure using different modules (aminoacid
biosynthesis, lipid metabolism...) as well as the entire full-range metabolic
network of the different organisms obtaining exactly the same results, so pointing
to a strong invariance of the metabolic characterization of the different
organisms, irrespective of the particular point of view. This is another, albeit
indirect, proof-of-concept of the fact that metabolic wiring is a unitary phenotype
of the cell.
The inter-organisms network dissimilarity matrix was first computed on 25
microorganisms, the clustering tree relative to this dissimilarity matrix is
depicted in Fig. 8.7, where a clear separation of the different species is evident.
To test the robustness of the obtained result, an addition of other 18
microorganisms (archaea) to a total of 43 units was made. The general tree is
reported in Fig. 8.8.
Fig. 8.7. Glycolysis/gluconeogenesis phenotypic tree in the case of the classification of 25
organisms.
Search WWH ::




Custom Search