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central TM domain undergoes counter-rotation with respect to the EC and CP
domains (Figs. 7.4a and 7.4c). Both motions induce an increase in the pore
diameter (Figs. 7.4b and 7.4d).
Fig. 7.4. Quasisymmetric twisting motion of heteropentameric nAChR. GNM mean-square (MS)
fluctuations of the global mode types I and II are shown, mapped onto a ribbon diagram of the
protein. The fluctuation values are color-coded on the nACHr structure (red:high, green:moderate,
blue:low). The black arrows indicate the phases of twisting directions from the correlated ANM
modes. The TM2 domains from the models of open-pore structures (magenta) calculated from
ANM eigenvectors and eigenvalues are compared with the starting close-pore structure (gray) for
type I (c) and type II (d) twists. Note the widening of the pore as a result of the twists ( Figure
adapted from Szarecka et al. , 2007 ).
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