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The effect of luoxetine complexation with stevioside is also manifested in a reduced sedative
action of the pharmacon on the background of chloral hydrate, a somniic drug.
Similar to GABA, complex ST:FL = 4:1 containing a 10 times reduced dose of the pharmacon
produces a positive effect on the mnestic abilities in animals (Shishkina et al., 2006).
Complexes of rebaudioside (RB) with nifedipine with the RB:NF ratio 2:1 and 4:1, containing
9 and 18 wt.% of the pharmacon, respectively, were synthesized using the solution method. Doses
ensuring high antiarrhythmic and standard antihypertensive activity were found for the complexes.
The overall (100%) antiarrhythmic effect was demonstrated by both complexes containing a 10- and
5-times reduced dose of nifedipine, respectively. Antiarrhythmic activity similar to that of nifedip-
ine was shown for complex RB:NF 2:1 at a ive-times reduced dose of the pharmacon.
11.2.1.14 Arabinogalactan
Arabinogalactans (Figure 11.22) belong to polysaccharides, which are widespread in plants (Clarke
et al., 1979; Ovodov, 1998; Arifkhodzhaev, 2000). Larch arabinogalactans, the content of which in
the wood reaches 15%, stand apart from these compounds. Arabinogalactan macromolecule is widely
branched. The backbone chain consists of d-galactose segments connected by β-(1-3)-glycoside bonds.
Side branches connected with the backbone chain by β-(1-6) linkages are d-galactose blocks con-
nected by β-(1-6)-bonds and d-arabinose blocks connected by β-(1-3)-bonds. In arabinogalactan com-
mercially derived from Western larch
Larix occidentalis
, the galactose to arabinose fragments ratio
increases to 7:1 from 2.33:1 with growth of molecular mass (Prescott and Graman, 1997).
HO
H
OH
H
H
H
H
O
HO
H
H
OH
OH
H
CH
I
CH
H
2
C
O
OH
H
H
H
O
H
HO
H
O
HO
H
H
H
H
H
O
OH
OH
OH
OH
OH
OH
H
CH
2
H
2
COH
H
2
C
H
H
2
C
O
H
H
OH
H
OH
H
H
H
O
H
O
H
H
HO
H
O
HO
HO
O
HO
H
H
H
H
O
O
O
O
OH
OH
OH
OH
H
2
C
H
2
C
H
2
C
H
2
C
H
H
H
H
O
O
O
O
H
H
H
H
HO
O
O
O
O
H
OH
H
OH
H
H
OH
OH
H
H
H
H
H
H
H
H
FIGURE 11.22
Arabinogalactan.
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