Environmental Engineering Reference
In-Depth Information
TABLE 11.1
Edema Index for Treated and Untreated Animals
Weight of Paw (mg)
Mean Edema
Index (%)
Relative
Edema Index
Animal
Number
Edema
Index (%)
Group Number
Treated
Untreated
1 (untreated)
1
193
160
20.6
20.3 ± 1.9
2
186
150
24.0
3
187
145
29.0
4
150
130
15.4
5
203
177
14.7
6
170
149
14.1
7
204
168
21.4
8
179
145
23.4
2 (peroral)
1
187
167
12.0
12.2 ± 1.6
2
183
173
11.6
3
173
160
8.1
4
178
156
14.1
5
174
162
7.0
6
170
154
10.4
7
204
176
15.9
8
174
163
6.7
9
179
144
24.3
10
152
170
11.8
3 (aerosol group)
1
200
177
13.0
7.3 ± 1.2
2
171
157
8.9
3
159
155
2.3
4
160
147
8.4
5
178
170
4.7
6
157
151
4.0
7
179
165
8.5
8
158
171
8.2
0.36 ± 0.06
Standard errors are shown in the last column.
mg per kg bw (group 3.1) and
d
= 9 nm, with the dose = 1.2 × 10
−5
mg per kg bw (group 3.2). The
aerosol number concentrations in the WB chambers were 7.1 × 10
2
and 7.4 × 10
5
cm
−3
, respectively.
The group 1 included again untreated mice being exposed to the pure air in the chambers. Each
group consisted of 8-10 animals. The lungs of animals from both group 3.1 and group 3.2 as well
as from the group 1 have a normal structure without any destructive and hemodynamic pathologic
changes (Figure 11.12). However, a moderate venous and arterial hyperemia was observed for all
the animals in group 3.1. Two animals of this group have revealed the focal emphysematous dilata-
tion of the respiratory bronchioles without any visible vascular bed reduction (Figure 11.13). All
the animals from group 3.2 have demonstrated the vascular and capillary hyperemia (which was
considerably stronger than in the case of group 3.1). A homogeneous venous deposition (presum-
ably ibrin) was observed. Besides, typical emphysematous signs, stronger than those in group 3.1,
were observed, that is, the dilatation of bronchioli and alveolar channels, alveolar wall thinning and
partial capillary bed reduction (Figure 11.14).
Search WWH ::
Custom Search