Environmental Engineering Reference
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20
18
16
14
12
(b)
10
8
6
4
2
(a)
0
0
2
4
6
8
10
12
14 16
2Θ (degree)
18
20
22
24
26
28
30
FIGURE 11.7
X-ray diffraction patterns of (a) original ibuprofen powder and (b) ibuprofen nanoparticles
formed via evaporation-nucleation route (mean particle diameter
d
= 85 nm).
1
/
N
α = −
⎛
n
n
⎞
⎟
out
1
(11.1)
⎜
( )
0
out
where
n
out
and
n
ou
( 0
are aerosol number concentrations at the outlets of the loaded and unloaded NOE
lines, respectively
N
is the number of chambers in the tandem (see Figure 11.3)
The rate
D
[s
−1
] of particle lung deposition per mouse can be written as
D F n
≈ α
(11.2)
where
F
(cm
3
/s) is the low rate through the NOE chambers tandem
n
is the arithmetic mean between the loaded NOE line inlet and outlet particle concentrations
One can also use the relative deposition rate:
D
n
D
0
=
= α
F
(11.3)
Figure 11.8 shows the relative deposition rate
D
0
as a function of the mean particle diameter. The
logistic regression analysis applied to the relative deposition rate data showed that there was a sta-
tistically signiicant correlation between the particle diameter and the relative deposition rate (
R
2
=
0.96). The itted curve is shown as a solid line. Using the function
D
0
(
d
) we determined the lung-
deposited dose (weight of the deposited particles) for the WB chambers inhalation experiments:
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