High Aspect Ratio Nanomaterials - Aerosols: Measurement, Dosimetry, and Health Effects - page 241

TABLE 10.1
Summary of Respiratory Effects if Inhalation Exposure to Carbon Nanotubes

Sample Information Test Conditions

Mass Median
Aerodynamic
Diameter ( μ m)

Exposure
Conc.
(mg/m 3 )

Diameter a
(nm)

Length a
( μ m)

Exposure
Period

Observation
Points

HARN Morphology Species Result Reference

MWCNT Agglomerates

and individual
tubes

— 0.5-40 183 M 6 h 30 1 day, 2

week, 6
week, 14
week

Subpleural ibrosis Ryman-

Rasmussen
et al. (2009a)

Agglomerates
and individual
tubes

30-50 0.3-50 0.71 M 6 h 100 1 day, 14 day Acute inlammation

(resolving).
Airway ibrosis in
allergically sensitized
mice only

Ryman-
Rasmussen
et al. (2009b)

Spherical
agglomerates

10-16 — 1.9, 2.0 R 6 h 11, 241 1 week,4

week, 13
week

Acute inlammatory
response with some
association to the
presence of
contaminating catalyst
(cobalt), which regressed
with time

Ellinger-
Ziegelbauer
et al. (2009)

Spherical
agglomerates

∼10 0.2-0.3 NA, -,3.05,

2.74,3.42

R 90 days

(6 h/day,
5 day/week,
13 week)

0.1, 0.4,
1.5, 6.0

0 week, 4
week, 13
week, 26
week

No detectable systemic
toxicity. Evidence of
particle overload
phenomena at
1.5 mg/m 3 + with
resultant inlammation
and ibrosis, borderline
changes at 0.4 mg/m 3

Pauluhn
(2010a)

(continued)