Biology Reference
In-Depth Information
tibialis posterior
muscle fibers are
significantly
improved in
animals treated
with COSs in a
dose-dependent
manner. COSs
display a
neuroprotective
effect
-
Chitooligosaccharides
(COSs)
Intraperitoneally
injections of 3 or
6 mg/kg body
weight of COSs
over 3-week
period
Sprague-
Dawley
rats
Sciatic
nerve
Nerve
crush
injury
-
Electrophysiological,
measurement of
withdrawal reflex
latency (WRL),
walking track
analysis, and
histological
evaluation
Saline
injections
3 weeks COSs promote
peripheral nerve
regeneration and
functional
recovery of
injured nerves.
COSs display a
neuroprotective
effect
Jiang,
Zhuge,
Yang, Gu,
and Ding
(2009)
Chitosan
tube
GDNF
GDNF blending
with chitosan
Lewis
rats
Sciatic
nerve
Nerve
transection
10
Histological
evaluation
Autograft
12 weeks Chitosan-
GDNF tube
enhances nerve
regeneration
process during
the initial stages
of nerve repair
Patel, Mao,
Wu, and
VandeVord
(2009)
Chitosan
tube
GDNF
GDNF blending
with chitosan
Lewis
rats
Sciatic
nerve
Nerve
transection
10
Functional gait
analysis and
sensitivity test
Autograft
12 weeks Chitosan-
GDNF tube
increases
functional
recovery
compared to
unblended
chitosan groups
Patel, Mao,
Wu, and
Vandevord
(2007)
