Biology Reference
In-Depth Information
Microporous
chitosan tube
(PGA)-oriented
filaments
dogs
Sciatic nerve Nerve
transection
histological
evaluation and
FluoroGold
retrograde tracing
30-mm
autograft
group
(positive
control) and
nongrafted
group
(negative
control)
nerve
continuity,
functional
recovery, and
target muscle
reinnervation in
the chitosan
PGA graft group
(2005)
Chitosan/
PLA tube
-
-
Rats
Sciatic nerve Nerve
transection
5
Electrophysiological
and histological
evaluation
Silicon
conduits and
autograft
group
12 weeks
Chitosan/PLA
tube results in
nerve
regeneration,
axon's quality,
and quantity
close to
autograft's group
Xie, Li, and
Zhao (2005)
Chitosan tube Hollow tube
-
Female
Beagle
dogs
Sciatic nerve Axotomy
-
IgG and IgM serum
analysis
Intact and
axotomized
control
groups
60 days
Chitosan
implants do not
affect the
immune
response
Rosales-
Cortes,
Peregrina-
Sandoval,
Banuelos-
Pineda,
Castellanos-
Martinez,
et al. (2003)
and Rosales-
Cortes,
Peregrina-
Sandoval,
Banuelos-
Pineda,
Sarabia-
Estrada, et al.
(2003)
Apatite/
chitosan tube
Hollow tube
-
Male
Sprague-
Dawley
rats
Sciatic nerve Nerve
transection
10
Histological
evaluation
10-mm
chitosan
tube
12 weeks
Apatite-treated
chitosan hollow
tube keeps its
shape in vivo and
induces nerve
Yamaguchi
et al. (2003)
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