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Table 1.5 Chitosan conduits and luminal framework modifications used in peripheral nerve repair cont'd
Intrinsic framework
Gap
size
(mm) Methods
Authors and
year
Nerve tube
Framework
Internal filler
Animal
Nerve
Injury
Controls
Follow-up
Outcome
Polylactic acid
(PLA)/
chitosan tube
Hollow tube
PLGA filler
Male
Sprague-
Dawley
rats
Sciatic nerve Nerve
transection
10
Electrophysiological
and histological
evaluation
10-mm
autograft
and 10-mm
silicone
conduit
group
12 weeks
Axonal
regeneration,
sciatic nerve
functional
recovery, and
muscle
reinnervation of
chitosan-PLA
group are close
to control group
Xie, Li, Gu,
Liu, and Shen
(2008)
Chitosan
Microgrooved
polymer
-
Male
Sprague-
Dawley
rats
Sciatic nerve Nerve
transection
12
Histological
evaluation
12-mm
silicone
group and
smooth
chitosan
conduits
6 weeks
Microgrooved
conduits
enhance
peripheral nerve
regeneration in
comparison with
the smooth
conduits
Hsu et al.
(2007)
Chitosan tube Sponge
Freeze-dried
chitosan gel
sponge
Male
Wistar
rats
Sciatic nerve Nerve
transection
8
Histological
evaluation
8-mm gap
without
chitosan
tube
implantation
4 months
Axonal
regeneration and
remyelination
Ishikawa
et al. (2007)
Chitosan tube Hollow tube
-
Rats
Sciatic nerve Nerve
transection
10 Walking track
analysis and
histological
evaluation
10-mm
autograft
12 weeks Decrease in
muscle atrophy,
increase in
axonal growth
and functional
recovery
Patel et al.
(2006)
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