Biology Reference
In-Depth Information
Table 1.5 Chitosan conduits and luminal framework modifications used in peripheral nerve repair
—
cont'd
Intrinsic framework
Gap
size
(mm) Methods
Authors and
year
Nerve tube
Framework
Internal filler
Animal
Nerve
Injury
Controls
Follow-up
Outcome
Polylactic acid
(PLA)/
chitosan tube
Hollow tube
PLGA filler
Male
Sprague-
Dawley
rats
Sciatic nerve Nerve
transection
10
Electrophysiological
and histological
evaluation
10-mm
autograft
and 10-mm
silicone
conduit
group
12 weeks
Axonal
regeneration,
sciatic nerve
functional
recovery, and
muscle
reinnervation of
chitosan-PLA
group are close
to control group
Xie, Li, Gu,
Liu, and Shen
(2008)
Chitosan
Microgrooved
polymer
-
Male
Sprague-
Dawley
rats
Sciatic nerve Nerve
transection
12
Histological
evaluation
12-mm
silicone
group and
smooth
chitosan
conduits
6 weeks
Microgrooved
conduits
enhance
peripheral nerve
regeneration in
comparison with
the smooth
conduits
Hsu et al.
(2007)
Chitosan tube Sponge
Freeze-dried
chitosan gel
sponge
Male
Wistar
rats
Sciatic nerve Nerve
transection
8
Histological
evaluation
8-mm gap
without
chitosan
tube
implantation
4 months
Axonal
regeneration and
remyelination
Ishikawa
et al. (2007)
Chitosan tube Hollow tube
-
Rats
Sciatic nerve Nerve
transection
10 Walking track
analysis and
histological
evaluation
10-mm
autograft
12 weeks Decrease in
muscle atrophy,
increase in
axonal growth
and functional
recovery
Patel et al.
(2006)