Biology Reference
In-Depth Information
polyvinyl
alcohol (PVA)
evaluation
(positive
control)
nongrafted
(negative
control)
regrowth and
remyelination.
Recovery of
compound
muscle axon
potential
(2011)
Chitosan tube Tube wall with
longitudinally
or randomly
oriented pores
-
Rats
Sciatic nerve Nerve
transection
15
Electrophysiology,
retrograde labeling,
and histological
evaluation
Autograft
4 weeks
Axonal
regeneration and
motor functional
recovery are
improved by
electrical
stimulation in
animals that
received
longitudinal
pore tube
compared to
control group
Huang, Hu,
et al. (2010)
and
Huang,
Lu, et al.
(2010)
Chitosan
nano-/
microfiber
mesh tube
Hollow tube
-
Beagle
dogs
Thoracic
sympathetic
nerve and
phrenic
nerve
Nerve
transection
10
Skin temperature
measurement, X-ray
imaging
-
12 months
Improvement of
nerve
regeneration;
restoration of
diaphragm
mobility
Matsumoto,
Kaneko,
Oda, and
Watanabe
(2010)
Freeze-dried
chitosan type-
III membrane
and freeze-
dried chitosan
type-III tube
End-to-end
neurorrhaphy
enwrapped by
chitosan
membrane,
10-mm
autograft
enwrapped by
chitosan
membrane and
10-mm
autograft
enwrapped by
chitosan tube
guides
-
Sprague-
Dawley
rats
Sciatic nerve End-to-end
neurorrhaphy
and nerve
transection
10
Extensor postural
thrust (EPT),
withdrawal reflex
latency (WRL), and
ankle kinematics
10-mm
nerve
autograft,
10-mm
PLGA tube
and end-
to-end
surgery
alone
20 weeks
Better nerve
regeneration in
chitosan type III
tubulization
group than
PLGA
tubulization
control group
Simoes et al.
(2010)
