Biology Reference
In-Depth Information
Intrinsic framework
Gap
size
(mm) Methods
Authors and
year
Nerve tube
Framework
Internal filler
Animal
Nerve
Injury
Controls
Follow-up
Outcome
Chitosan/
polyglycolic
acid tube
-
-
55-
year-old
male
human
patient
Median
nerve
Nerve
discontinuity
30
Compound muscle
action potential
recording and
ninhydrin test
-
3 years
Recovery of
palm abduction
of the thumb and
thumb-index
digital
opposition;
reproducible
compound
muscle action
potential of the
right abductor
pollicis
Gu et al.
(2012)
-
Microcrystallic
chitosan gel
-
Male
Wistar
rats
Sciatic nerve Nerve
transection
10
Autotomy behavior
and histological
evaluation
Nerve
transection
without
chitosan gel
implantation
20 weeks
In chitosan
group neuroma
formation,
extraneural
fibrosis are
reduced in
comparison to
control group.
There is no
difference in
autotomy
behavior
between groups
Marcol et al.
(2011)
Chitosan
membranes
Porous
structure
-
Female
Wistar
rats
-
Subcutaneous
implantation
-
Histological
evaluation
-
8 weeks
Chitosan
membranes
owing their
porous structure
and chemical
modifications
and display high
affinity to
cellular systems
Simoes et al.
(2011)
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