Biology Reference
In-Depth Information
Table 1.1 Types of chitosan conduits used in spinal cord repair
Intrinsic framework
Internal
filler
Gap size
(mm)
Authors
and year
Nerve tube Framework
Animal
Injury
Methods
Controls
Follow-up
Outcome
Chitosan
-
-
Female
Sprague-
Dawley
rats
Laminectomy
T8 vertebral
level
2
Histological
evaluation
Degradable
polyglycolide and
nondegradable
expanded
polytetrafluoroethylene
tubes
12 months Chitosan, in
comparison with the
other tested materials,
does not elict immune
response. At
12 months,
postimplantation
chitosan is not
degraded
Kim
et al.
(2011)
Chitosan
membrane
-
-
Guinea
pigs
Complete
transection or
compression
injury in the
midthoracic
region
-
Somatosensory
evoked potential
(SSEP)
Subcutaneous injection
of Ringer's solution
2 weeks
Topical application of
chitosan after
complete transection
or compression
restored the
conduction of nerve
impulses through the
length of spinal cord
Cho,
Shi, and
Borgens
(2010)
Chitosan
tube
Rat
intercostal
nerve from
T7 to T11
Peripheral
nerve graft
Female
Sprague-
Dawley
rats
Laminectomy at
T7-T9 and
spinal cord
compression at
T8 with a 50-g
clip for 1 min
8mm
length
and
1.8 mm
diameter
Basso-Beattie-
Bresnahan (BBB) test,
anterograde axonal
tracing with biotin
dextran amine, and
histological evaluation
Empty
chitosan
tube
14 weeks Chitosan tube,
containing peripheral
nerve graft, contains a
higher number of
myelinating axons
compared with
chitosan tube alone.
SCs from the
peripheral nerve graft
have high myelination
capacity. Chitosan
tube shows excellent
biocompatibility
Nomura
et al.
(2008)
