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axons in injured nerves; after femoral nerve injury, L1 overexpression had
no impact on the time course and degree of functional recovery, but mye-
lination in the motor and sensory femoral nerve branches was significantly
improved and loss of perisomatic inhibitory terminals on motoneurons was
attenuated in the transgenic mice (
Guseva et al., 2011
). Recently, we
showed that constitutive ErbB2 receptor overexpression improves nerve
regeneration following traumatic injury, possibly through the upregulation
of soluble NRG1 isoforms (
Ronchi et al., 2013
).
6. CONCLUSIONS
Recent advances in peripheral nerve regeneration research have
strengthened the view that the process of nerve regeneration and target rein-
nervation is quite complex and involves several factors. Keeping in mind the
complexity of the whole process is thus very important for improving our
knowledge on peripheral nerve regeneration, especially in the perspective of
translating basic science results to the clinics.
Figure 8.2
synthesizes this con-
cept: in fact, it is important, but not enough, to study the involvement of a
Figure 8.2 Scheme representing the complexity of the regenerative process that occur
after a peripheral nerve injury.
