Biology Reference
In-Depth Information
Table 6.1 Major neurotrophic factors affected by physical exercise
—
cont'd
Role in
neuroprotection
and
neuroregeneration
Expression during
peripheral nerve
regeneration
Neurotrophic
factor
Pattern of
expression
Effect of physical
activity
Receptor
References
Expression of trkB
receptors is
increased by exercise
Ghiani et al. (2007)
,
Qin et al. (2006)
,
Wood et al. (2011)
BDNF and trkB
expression is
required for the
nerve-regenerating
effect of active and
passive exercises
Sohnchen et al.
(2010)
,
Wilhelm
et al. (2012)
NT-3 and trkC are
upregulated by
physical exercise in
both intact spinal
cord and muscle
Gomez-Pinilla et al.
(2001)
,
Ying, Roy,
Edgerton,
and
Gomez-Pinilla
(2003)
NT-3
trkC
(high
affinity)
p75
NTR
(low
affinity)
Neuronal survival
Axonal sprouting
Axonal elongation
Possible
contribution for
preferential motor
reinnervation
Synaptogenesis
and synaptic
plasticity
Maintenance of
muscle trophism
Present in higher
concentrations in
sensory than in
motor nerves
NT-3 is
predominantly
expressed and
produced by
muscle
trkC is abundantly
expressed in
motoneurons
NT-3 is produced
by Schwann cells in
injured nerves
(likely main source
of NT-3 during the
initial nerve
response to injury)
