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(COX-2) immunoexpression was lower in laser-treated group. COX-2 is a
key enzyme in conversion of arachidonic acid to prostanoids (
Renn´ et al.,
2011
). The expression of COX-2 is relevant to many pathological processes,
including inflammation and tissue repair. In the present study, laser irradi-
ation significantly increased CK activity and AChR level in time periods of
30-60 days in comparison with the nonirradiated gastrocnemius muscles. At
the cell level, we also found increased DNA synthesis and CK activity in
young and mature skeletal muscle. The induced biochemical changes
may be attributed to trophic signal for increased activity of CK, thus preserv-
ing a reservoir of high-energy phosphate available for quick resynthesis of
ATP. These findings are supported by early results by
Bolognani and
Volpi (1991)
and
Passarella et al. (1984)
who showed that laser irradiation
increased ATP production in the mitochondria. The present study and
our previous publication (
Rochkind et al., 2009
) suggest that laser photo-
therapy may enhance biochemical activity of the muscle to overcome stress
conditions.
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