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In-Depth Information
CHAPTER FOUR
Phototherapy and Nerve Injury:
Focus on Muscle Response
,1 , Stefano Geuna { , Asher Shainberg *
* Faculty of Life Science, Bar-Ilan University, Ramat-Gan, Israel
Division of Peripheral Nerve Reconstruction, Department of Neurosurgery, Tel Aviv Sourasky Medical
Center, Tel Aviv University, Tel Aviv, Israel
{ Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
1 Corresponding author: e-mail address: rochkind@zahav.net.il
,
Shimon Rochkind *
Contents
1.
Introduction
99
2. Phototherapy Increases Skeletal Muscle Biochemical Activity
101
3. Discussion and Future Perspectives
105
References
107
Abstract
Preservation of biochemical processes in muscles is a major challenge in patients with
severe peripheral nerve injury. In this chapter, we address the effects of laser irradiation
and biochemical transformation in muscle, using in vitro and in vivo experimental
models. The authors attempt to explain the possible mechanism of laser phototherapy
applied on skeletal muscle on the basis of literature review and new results. A detailed
knowledge of the evolution of endplates acetylcholine receptors and creatine kinase
activity following laser irradiation can help to understand the therapeutic effect of laser
phototherapy on muscle. This study showed that the laser phototherapy increases bio-
chemical activity in intact muscle and thus could have direct therapeutic applications on
muscle, especially during progressive atrophy resulting from peripheral nerve injury.
1. INTRODUCTION
Posttraumatic muscle denervation is a common and disabling out-
come of various types of accidents which often involve young people
( Campbell, 2008 ). Time to reinnervation is one of the most important
Part of this work is taken from Dr. Shimon Rochkind's Ph.D. dissertation
 
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