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functional, macronuclear form in
Sterkiella histriomuscorum
requires all three
operations.
Creation of the Odd/Even Pattern of MDSs in the
α
TP and the
DNA
pol
α
Gene
The regular odd/even pattern of MDSs in the
genes implies
a coordinated formation of MDSs by insertion of IESs during evolution. A
model describing coordinated formation of MDSs in the micronuclear
α
TP and DNA
pol
α
α
TP
gene in
Sterkiella nova
or
Stylonychia mytilus
is presented in Figure 9.28 [12].
Figure 9.28
A model to explain the creation of the odd/even pattern of macronuclear
destined segments (MDSs) in the
α
TP gene. (a) A loop of AT-rich DNA aligns with
the original
α
TP gene that has no internal eliminated segments (IESs). (b) A series
of recombinations between the loop of AT-rich DNA and the
α
TP gene creates an
odd/even pattern of MDS 1-12. MDSs 13 and 14 are formed by two separate, inde-
pendent insertions of IESs. (c) The final order of MDSs in the
α
TP gene. Redrawn
from Prescott et al. [12].
