Chemistry Reference
In-Depth Information
Hydroxypropyl Methylcellulose Phthalate
Structure
RO
O
OH
RO
OR
, R is H, CH
3
,orCH
3
CH(OH)CH
2
O
O
OR
OR
O
H
OR
n/
2
CH
3
O
O
O
O
OH
O
OH
or
Synonyms
HPMCP, hypromellose phthalate, cellulose
phthalate hydroxypropyl methyl ether,
methylhydroxypropyl cellulose phthalate,
Mantrocel HP-55
Molecular weight range
(g/mol)
20,000-200,000
Solubility parameter,
δ
(MPa
0.5
)
28
T
g
range (
C)
133
-
137
°
T
m
range (
C)
150
°
Water uptake (% water
at 75% RH)
7
-
8%
Solvent solubility
Readily soluble in a mixture of acetone and
methyl or ethyl alcohol (1:1), in a mixture of
methyl alcohol and dichloromethane (1:1),
practically insoluble in dehydrated alcohol and
very slightly soluble in acetone
pH range where soluble
>
5.0 (HP-50),
>
5.5 (HP-55)
Amenable methods of
dispersion manufacture
Melt extrusion, spray drying
Use in marketed
dispersion products
None
Grade
MW
T
g
(or
T
m
)
(
°
C)
HP-50
84,000
137
HP-55
78,000
133
HP-555
132,000
-
