Chemistry Reference
In-Depth Information
Hydroxypropyl Methylcellulose
Structure
RO
O
OH
RO
OR
RisH,CH
3
,orCH
3
CH(OH)CH
2
O
O
OR
OR
O
H
OR
n/
2
Synonyms
HPMC, hypromellose, Hypromellosum, Methocel,
Pharmacoat, Metolose
Molecular weight range
(g/mol)
10,000
-
1,500,000
Solubility parameter,
δ
(MPa
0.5
)
23.8
T
g
range (
°
C)
170-180
Water uptake (% water at
75% RH)
∼
10%
Solvent solubility
Practically insoluble in chloroform, ethanol (95%), and
ether, but soluble in mixtures of ethanol and
dichloromethane, mixtures of methanol and
dichloromethane, and mixtures of water and alcohol
pH range where soluble
1-10
Amenable methods of
dispersion manufacture
Melt extrusion, spray drying
Certican
, Intelence
, Isoptin SRE-240
, LCP-Tacro
,
Nivadil
, Prograf
, Sporonox
, Zortress
Use in marketed dispersion
products
