Chemistry Reference
In-Depth Information
14.1.1.2 Solubility Parameter
Solubility parameters reported are the Hilde-
brand solubility parameter (
δ
) and were taken from Ref. [2].
The glass transition
temperature (
T
g
) and melting temperature (
T
m
) were taken from Ref. [2] and are given as
a range since different molecular weights will change these properties. Some semi-
crystalline polymers will exhibit both temperatures and these are presented in the table.
Where possible, the grade, molecular weight, and glass transition temperature (
T
g
) are
given.
14.1.1.3 Glass Transition and Melting Temperatures
Solvent solubility was obtained from Ref. [1].
Extent of solubility was listed when possible based on de
14.1.1.4 Solvent Solubility
nitions in:
1
Descriptive Term
Parts of Solvent Required for 1 Part of Solute
Very soluble
<
1
Freely soluble
1-10
Soluble
10-30
Sparingly soluble
30-100
Slightly soluble
100-1000
Very slightly soluble
1000-10,000
Practically insoluble or insoluble
10,000
The values for pH solubility were taken
from Ref. [2]. Many enteric polymers are only soluble near neutral pH (5
14.1.1.5 pH Range Where Soluble
-
7), while
others are soluble over a larger pH range.
Melt extrusion and spray
drying were the primary production methods considered in this section. The methods
are based on studies and products that employ the various polymers. It should not be
considered a de
14.1.1.6 Amenable Methods of Preparation
nitive option, as innovations may lead to more polymers being used in
both production methods.
c
polymers is based on package inserts and open literature as of the publication date of this
topic.
14.1.1.7 Use in Marketed Dispersion Products
The use of the speci
1
United States Pharmacopeia and National Formulary (USP 34-NF 29), Rockville, MD: United States
Pharmacopeia Conventions; 2011, 6.
