Chemistry Reference
In-Depth Information
(a) Regression and residual plots of the normailized
t
15
dissolution model
6
4
2
0
-2
-4
-6
-8
SDD
d
50
(
μ
m)
Small
Large
Normalized
t
15
dissolution (%) predicted
Normalized
t
15
dissolution (%) predicted
(b) Summary of fit
R
2
0.831
Adjusted R
2
0.826
Root mean square error
2.36
Mean of response
Observations (or sum
weights)
84.0
241
(c) Parameter estimates of the normalized
t
15
dissolution mod
el
Prob>|
t
|
Term
Intercept
<0.0001
d
50
(
m)
<0.0001
μ
SDD bulk density (g/cm
3
)
<0.0001
Average hardness of 5 tablets (kP)
<0.0001
(
d
50
(
μ
m)-
x
) x (SDD bulk density (g/cm
3
)-
y
)
<0.0001
(SDD bulk density (g/cm
3
)-
y
) x (average hardness of 5 tablets (kP)-
z
)
0.0003
(Average hardness of 5 tablets (kP)-
z
) x (average hardness
of 5 tablets (kP)-
z
)
<0.0001
(d) Prediction profiler for dissolution
SDD
d
50
(
μ
m)
SDD bulk density
(g/cm
3
)
Average hardness of
5 tablets (kP)
Figure 11.9.
Normalized
t
15
dissolution model.
