Chemistry Reference
In-Depth Information
(a) Particle size regression (left-hand plot) and residuals (right-hand plot).
Open = FSD12.5; closed = PSD4 a
20
10
0
-10
-20
d
50
predicted
P
< 0.0001
d
50
predicted
(b) Summary of fit
2
R
0.758
2
Adjusted
R
0.747
Root mean square error
7.30
Mean of response
80.4
Observations
162
(c) Particle size sorted parameter estimates
Term
t
Ratio
Prob > |
t
|
Spray dryer type
11.42
<0.0001
*
Feed paressure (bar)
T
out
(
°
C)
-11.26
<0.0001
*
<0.0001
*
-10.93
TS (%)
7.23
<0.0001
*
Nozzle diameter (mm)
6.63
<0.0001
*
00.0004
*
TS (%) x nozzle diameter (mm)
3.63
Feed pressure (bar) x spray dryer type
3.56
00.0005
*
(d) Prediction profiler showing magnitude of the effect of each significant process
variable on median particle size (
d
50
) for telaprevir SDD
TS (%)
Nozzle
diameter (mm)
Feed pressure
(bar)
T
out
(°C)
Spray
dryer type
Figure 11.6.
Particle size model for telaprevir SDD.
