Chemistry Reference
In-Depth Information
9
SPRAY DRYING AND SCALE-UP
Daniel E. Dobry, Dana M. Settell, and John M. Baumann
Bend Research, Inc., Bend, OR, USA
9.1 INTRODUCTION
Spray drying is a versatile, continuous process that is commonly used in the food,
chemical, and pharmaceutical industries. The spray drying process converts liquid
feedstocks including solutions, slurries, and suspensions into dry powders. Spray drying
is applicable to a wide range of materials and across a wide range of scales. Furthermore,
spray drying offers fast drying kinetics,
flexibility in achieving the desired product
properties, mild processing temperatures, and short residence times, making it an ideal
process for manufacturing amorphous dispersions.
Spray drying has demonstrated scalability from milligram quantities of active
pharmaceutical ingredient (API) during formulation screening to metric ton quantities
at commercial scale. Minimal use of API during development and scale-up and
demonstrated commercial viability make spray drying an ef
cient and effective man-
ufacturing option for amorphous dispersions [1
3]. This chapter discusses amorphous
dispersions manufactured using the spray drying process, which are referred to as spray-
dried dispersions (SDDs). Key aspects of spray drying equipment, process development,
and scale-up are covered.
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