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Figure 3.8.
Schematic for (a) the SPADS dispersion screening approach and (b) experimental
procedure for SAPDS assays. (Reproduced with permission from Ref. 16. Copyright 2013,
Elsevier.)
films prepared in aluminum
DSC pans using the same solvents as those in the dissolution assay. The 20
The interaction assay was performed on drug
-
polymer
-
100 nm thick
films were analyzed by FTIR microscopy. The amide I carbonyl stretching vibrations
(between 1624 and 1640 cm
1
) were used to investigate the amide group as a hydrogen
bond acceptor. Peak positions were compared with the pure drug and shifts between
