The Cell-Substrate Surface Interaction - Sensor Technology in Neuroscience - page 82

notion of capture of circulating progenitor cells by CD34 antibody placed on
the device surface was introduced. 103 In our own work, we are studying the
possibility that increased biocompatibility of the steel surface can be combined
with oriented antibody via use of a covertly bound Fab1 fragment. 104 The
former concept is designed to reduce protein absorption and the latter the
maximization of antibody interaction cell surface receptors. An analogous
approach has been employed in biosensor technology for detection purposes,
but instead of an antibody for cell capture, a probe is embedded in the anti-
fouling layer. The overall strategy employed to enhance biocompatibility in this
case is depicted in Figure 2.17.

d n 4 t 3 n g | 0

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