Biomedical Engineering Reference
In-Depth Information
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Figure 1.22
Detection of nucleic acid hybridization on surface of optical fiber via
excitation with evanescent radiation.
Figure 1.23
Multiple optical fibers can be employed in order to enhance sensitivity of
detection.
1.4.3.2 Surface Plasmon Resonance
This technique has very often been regarded as representing the most profound
commercial success in terms of biosensor technology, with the possible
exception of the glucose electrode. From its genesis at the University of
Linko¨ ping in Sweden in the 1980s, the initial commercial sale of various surface
plasmon resonance instruments has changed hands several times and also has
been the subject of strong competition. The technique as applied to biochemical
detection science has been reviewed a number of times.
109-115
To the non-specialist the physics of the generation of surface plasmon waves
is somewhat dicult
to comprehend. At
the heart of
the effect
is the
