Biomedical Engineering Reference
In-Depth Information
network function such as autocorrelograms, cross-correlograms and sophis-
ticated probabilistic models of network connectivity. Recently, an analysis of
ignition sites (burst leaders) and leader-follower phase delay distributions has
opened another window to the internal dynamics of networks and has revealed
pharmacological sensitivities.
78
It has also been possible to determine disso-
ciation constants for bicuculline, gabazine, and trimethylolpropane phosphate
(TMPP) using frontal cortex cultures on MEAs with excellent agreement to
data from more conventional assays.
79
Table 3.1 forms the database of neuromodulators profiles 'finger prints' of
concentration-dependent activity changes induced by a compound with known
d
n
4
t
3
n
g
|
7
Table 3.1 Database of substances whose 'fingerprint' activity has been
established using MEA technologies.
71
(Reprinted by kind
permission of Elsevier BV.)
Receptor agonists
Anesthetics/analgesics
Gap junctions
Acetylcholine
Fentanyl
Carbenoxolone
AMPA
Ketamine
1-Octanol
Baclofen
Levomethadone
Mefloquine
GABA
Morphine
Sodium propionate
Glycine
Phenobarbital
n
3
.
NMDA
Propofol
Phytopharmaceuticals
Neuropeptide Y
Remifentanil
Passion flower
Norepinephrine
Sufentanil
St Johns Worth
Pregnanolone
Thiopental
Valeriana
Substance P
Tramadol
Particles and ions, metals
Receptor antagonists
Anticonvalsants/sedatives
TiO
2
,C,Fe
2
O
3
,As
2
O
3
,
APV
Carbamazepine
As
2
O
5
, MeAs(III),
MeAs(V), Mg
21
,Mn
21
,
La
31
,C
3
H
9
ClSn
Atropine
Clonazepam
Benzoquinone
Diazepam
Bicuculline
Flunitrazepam
Flumazenil
Gabapentin
Other
L-512,804
Levetiracetam
Ab42
L-733,060
Phenytoin
Albumin
MK 801
Topiramate
Ammonia
Muscimol
Valproate
Apomorphine
NBQX
Zolpidem
Cisplatinum
Picrotoxin
Cortisol
SCH50911
Opioids
Cyclosporine A
SCS
Dermorphine
DEET
Strychnine
DAMGO
DMSO
DPDPE
EBAAP
Antidepressants/neuroleptics Dynorphin A
Ethanol
Amitriptyline
Enkephaline
Lithium heparin
Apomorphine
Endomorphine I
รพ
II
Neurotensin
Clozapine
Nalorphine
Nocodazole
Fluoxetine
Naloxone
Tacrolimus
Fluvoxamine
Nociceptin
Tetrodotoxin
Haloperidol
U50488
Wortmannin
LiCl
