Biomedical Engineering Reference
In-Depth Information
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Figure 3.10
A living neural network is grown on a microelectrode array. The activity
is recorded, processed in real time and then used to control a robot.
(Reprinted by kind permission of Springer Verlag.)
hinder the transport between the neuron membrane and the working
electrodes.
3.7 Fabrication
The function of a neuronal network is significantly affected by the neurons'
structure and environment, as well as the architecture and organization of the
neuronal network. Fabrication of electronic interfaces (to stimulate and detect
neuronal activity) is an opportunity to influence and impose an artificial design
on neuronal networks to engineer their function. The physical constraints of
the in vitro environment can direct the growth of neuronal networks and the
interconnection. Furthermore, placement of electrodes in strategic locations (in
the frame of the platform) assists in stimulation of neurons at specific and
critical locations within the network to enhance specific applications. This
placement thereby allows for observations of the activity of the system at
targeted sites. Fabrication of in vitro neuronal network platforms and the
placement of electrodes have far reaching implications in the outcome of
experiments and,
therefore, demand careful consideration of
the cells'
physiology as well as their interconnection in the design stage.
