Biomedical Engineering Reference
In-Depth Information
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Figure 3.5
(A) Recorded potentials from a neuron cultured on a CMOS chip.
(B) After axotomy. (C) 24 h later neurites are regrown from the cut tip.
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(Reprinted by kind permission of Elsevier Science.)
generates a particular field potential). Such experiments can used to investigate
the neuron regeneration process as well as its plasticity. Additionally, this
experimental setup may help to evaluate the most optimal use of stem cells in
the repopulation or replacement of brain cells, which have been devastated by
injury or illness (e.g. stroke, Alzheimer's disease, Parkinson's disease, epilepsy,
stress injury, leukemia or depression).
3.5 Microelectrode Array Structures
Some of the first in vitro studies with neurons were performed using glass
micropipette electrodes.
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As each electrode must be held and tediously
