Agriculture Reference
In-Depth Information
perform additional studies to the 90-day
rodent feeding study as dei ned by Guideline
No 408 (OECD, 1998) in order to assess
ef ectively the risks associated with the use
of new GM traits. h erefore, in the context
of GM food and feed risk assessment, long-
term and multi-generational studies should
be conducted only in a case-by-case
approach, after reasonable doubt still exists
following a 90-day feeding trial.
Complementary fundamental studies
should be performed but with a strong need
for harmonization between studies, as well
as with a broader spectrum of animal
models. h is type of research would help to
choose the most ei cient experimental
design to assess the risks associated with
new GM traits by revealing the physiological
dif erences arising between short-, mid- and
long-term tests.
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Acierno, R., Hemre, G.I., Maffi a, M.,
et al
.
(2008) Atlantic salmon (
Salmo salar
L.) parr fed
genetically modifi ed soybeans and maize:
histological, digestive, metabolic, and
immunological investigations.
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Veterinary Science
84(3), 395-408.
Baranowski, A., Rosochacki, S., Parada, R.,
Jaszczak, K., Zimny, J. and Połoszynowicz, J.
(2006) The effect of diet containing genetically
modifi ed triticale on growth and transgenic DNA
fate in selected tissues of mice.
Animal Science
Papers and Reports
24, 129-142.
BEETLE (2009) Long-term effects of genetically
modifi ed (GM) crops on health and the
environment (including biodiversity). Executive
Summary and Main Report. Federal Offi ce of
Consumer Protection and Food Safety (BVL),
Berlin, 132 pp. + 6 Annexes (
http://ec.europa.
accessed
6
November 2012).
Brake, D.G. and Evenson, D.P. (2004) A
generational study of glyphosate-tolerant
soybeans on mouse fetal, postnatal, pubertal
and adult testicular development.
Food and
Chemical Toxicology
42, 29-36.
Brake, D.G., Thaler, R. and Evenson, D.P. (2004)
Evaluation of Bt (
Bacillus thuringiensis
) corn on
mouse testicular development by dual
parameter fl ow cytometry.
Journal of Agricultural
and
Food Chemistry
52, 2097-2102.
Buzoianu, S.G., Walsh, M.C., Rea, M.C., Cassidy,
J.P., Cotter, P.D., Ross, R.P.,
et al
. (2012a) Effect
of feeding genetically modifi ed Bt MON810
maize to 40-day-old pigs for 110 days on growth
and health indicators.
Animal
6(10), 1609-1619.
DOI:10.1017/S1751731112000249.
Buzoianu, S.G., Walsh, M.C., Rea, M.C.,
O'Donovan, O., Gelencser, E., Ujhelyi, G.,
et al
.
(2012b) Effect of feeding Bt maize to sows
during gestation and lactation on maternal and
offspring immunity and fate of transgenic
material.
PLoS One
7, 10:e47851.
Buzoianu, S.G., Walsh, M.C., Rea, M.C., Cassidy,
J.P., Ryan, T.P., Ross, R.P.,
et al
. (2012c) Trans-
generational effects of feeding genetically
modifi ed maize to nulliparous sows and
offspring on offspring growth and health.
Journal
of
Animal Science
91(1), 318-330.
DOI:10.2527/jas.2012-5360.
CERA (2012) GM Crop Database. Center for
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h e French Academy of Agriculture has
awarded Dr Agnes Ricroch the Limagrain
Prize 2012.
ANSES [Agence nationale de sécurité sanitaire de
l'alimentation, de l'environnement et du travail]
(2011) Opinion of the French Agency for Food,
Environmental and Occupational Health and
Safety. Recommendations for carrying out
statistical analyses of data from 90-day rat
feeding studies in the context of marketing
authorisation applications for GM organisms.
Request No 2009-SA-0285 (
http://www.anses.
sed 6 June 2013).
Appenzeller, L.M., Munley, S.M., Hoban, D., Sykes,
G.P., Malley, L.A. and Delaney, B. (2008)
Subchronic feeding study of herbicide-tolerant
soybean DP-356O43-5 in Sprague-Dawley rats.
Food and Chemical Toxicology
46(6), 2201-
2213.
Aulrich, K., Boehme, H., Daenicke, R., Halle, I. and
Flachowsky, G. (2001) Genetically modifi ed
feeds in animal nutrition: 1st communication:
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(Bt) corn in poultry, pig
and ruminant nutrition.
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